NESTLÉ® NAN® INFINIPRO® 4 Children Milk Powder
NESTLÉ® NAN® INFINIPRO® 4 Children Milk Powder
Specially formulated for healthy children from 36 months onwards
Edge cutting science with over 150 years science leadership
NESTLÉ® NAN® upholds the commitment to nurture the next generation, with more than 150 years of expertise and relentless researches and innovations in early childhood nutrition, now presents a new upgraded formula – NESTLÉ® NAN® INFINIPRO® formula. Apart from the unique good milk protein which provides high-quality and good quantity of protein to support babies’ healthy growth. It also includes active good milk ingredient blend (5 HMO Complex^ and BL active probiotics) and pHF-W. Benefiting from NESTLÉ’s advanced R&D knowledge in children’s metabolic health, immunity and allergy prevention, guarding baby's healthy development in various aspects.
Upgraded Good milk Essence Power Contributes to Dual Growth Power*
Apart from the unique good milk protein which provides high-quality and good quantity of protein to support babies’ healthy growth. It also includes active good milk ingredient blend (5 HMO Complex^ and BL active probiotics) and pHF-W. Benefiting from NESTLÉ’s advanced R&D knowledge in children’s metabolic health, immunity and allergy prevention, guarding baby's healthy development in various aspects.
Committed to Science , Develops “High Quality - Good Quantity” Protein
Contributes to Metabolic Growth Power
Nutritional intake during the first 1000 days is important. Protein plays an important role in the growth, metabolism as well as fat accumulation, especially in the early growing stage1-3. Metabolism refers to digestion, decomposition and conversion of food into energy as an important process of growth. Select a “good protein with good essential amino acid profile” 4,5 which provides “High Quality - Good quantity” protein, reduce the burden of metabolic system, support babies’ healthy growth▾.
• High quality: Amino acid combination from cow’s milk may not fits babies’ need. Excessive protein intake (and certain amino acids) during early stage may increase obesity risk2.
• Good quantity: Protein level in cow’s milk is 3 times higher than natural lactating secretion6. Studies show that babies fed with milk with higher protein level in early stage, has 2.43 times7 higher risk of obesity when they reach the age of 6 and will also have higher risk of having other related health problems in the future.
Support immune development
• Research shows that the bioactive components in natural lactation secretion- HMOs help support gut health and immune system development8,9.
• Research shows that natural lactating secretion contains HMOs8-10 and categorized into 3 categories9,10.
• HMOs’ actions are specific, they are functionally and structurally unique to each type of HMO, hence the more diverse the HMO content is, the more benefits it can bring 11-25.
Diverse blend that covers all 3 HMO categories evaluated and authorized for use by 2 authorities
Precisely optimized HMO diversity – in terms of types, abundance and functions
• Scrupulously select the key HMOs (2’FL, LNT, 6’SL, 3’SL and DFL). These 5HMOs are among the most abundant types in its category, covering the three HMO categories, providing more diversity compare with other brands on the market.
• 5HMOs are generally recognized as safe and approved by 2 authorities, including the US Food and Drug Administration (FDA) and European Food Safety Authority (EFSA)26-33.
Preclinical studies show that 5HMOs support immunity in more different ways,while single HMO is not able to provide as such, supporting the development of immune systems and build better foundation. Different types of HMOs may help support:
|Reduce pathogen infection risk||Inhibit pathogen growth||Protect gut health|
|• Stop pathogens from entering baby’s gut||• Inhibit the growth of different pathogens||• Nurture growth of different gut beneficial bacteria|
|• Reduce the risk of different pathogens infections and diseases||• Reduce different inflammatory factors||• LNT is the most used by probiotics|
BL probiotic supports gut health and immune system development35.
Increase Anti-virus-specific-IgA secretion up to 4 times34
• Immunoglobulin (lgA) plays an important role in immune function. It is clinically proven that for babies taking products containing BL probiotics, their level of the anti-virus-specific IgA secretion was found to be 4 times more336##。
Reduce diarrhea risk by 49%35**
• Research shows that babies taking formula with added BL probiotic for 4 months has reduced diarrhea risk by 49%35**.
• Select 100% Whey Protein which is easier to digest■ .
• Through the unique precise hydrolysis technology, reduce the antigenicity of milk protein, helps prevent allergies39-41 and easy to digest42.
• According to the 20 years landmark clinical study sponsored by the German government, pHF-W is clinically proven to reduce risk of eczema by up to 41% 41**▴。
• The only pHF-W with EU approval on safety and suitability to be used on all term, healthy non breastfed infants43.
• Nestle’s pHF-W safety has been assessed and authorized by EFSA44-45.
Plant-based Packaging Design
Together, Let's Build a Sustainable Future
Together, Nuturing a Healthier Generation! NESTLÉ has shouldered its responsibility and developed the upgraded NESTLÉ® NAN® INFINIPRO® Formula to support Earth's sustainable development. Apart from having widely and infinitely recyclable tin can body and inner foil cover, we proactively use environmentally-responsible plant-based plastic lids and scoop, in replacement of traditional fossil fuels and other non-recyclable packaging materials. These plant-based plastic materials are approved by TUV Austria### and they share similar functionality and outlook as traditional lids and scoops, but they are made with lower carbon footprint which helps develop a sustainable future for our babies.
Together with NAN, caring for the environment through packaging innovations
NESTLÉ® NAN® INFINIPRO® Formula's scoop is made with HDPE Type 2 plastic, and you can put it in the three-colour recycle bins on the roadside to deliver to recycle plant. As the lid belongs is made with LDPE Type 4 plastic, the three-colour recycle bin will not handle non-bottle-shaped plastic, you will need to deliver to specific location for recycling. You can refer to [email protected] Waste Reduction page to locate the closest recycling centres. Together, with you, we can care for the environment and nourish your child's every possible.
1. Koletzko, B., et al. (2009). The American Journal of Clinical Nutrition, 89(Suppl), 1502S-1508S.
2. Luque, V., et al. (2016). Nutrition and metabolic insights, 8(Suppl 1), 49–56.
3. Koletzko, B., et al. (2009). The American Journal of Clinical Nutrition, 89(6), 1836–1845.
4. Zhang, Z., et al. (2013). Nutrients, 5, 4800-4821.
5. Nestlé Internal data. (2020). Nestlé Research Centre.
6. Michalesen, K.F. & Greer, F.R. (2014). Am J Clin Nutr, 99 (suppl), 718S-22S.
7. Weber, M., et al. (2014). Am J Clinc Nutr,99, 1041-1051.
8. Bode, L. (2012). Glycobiology, 22(9), 1147-1162.
9. Donovan, S.M., & Comstock, S.S. (2016). Ann Nutr Metab,69 (Suppl 2), 42-51.
10. Ninonuevo, M.R., et al. (2006). J Agric Food Chem, 54(20), 7471-80.
11. Alliet P, et al. (June 2020). Abstract at the 6th WCPGHAN, Copenhagen, Denmark.
12. Laucirica, D.R., et al. (2017). J Nutr,147(9),1709-1714.
13. Duska-McEwen, G., et al. (2014). Food Nutr Sci,5,1387-98.
14. He, S., et al. (2016).Gut, 65(1), 33-46.
15. Storm, H. M., et al. (2019). Global Pediatric Health, 6, 1-10.
16. Rochat, F., et al. (June 2020c). Abstract presented at: 6th WCPGHAN, Copenhagen, Denmark.
17. Cravioto, A., et al. (1991). J Infect Dis,163(6), 1247-55.
18. Lin, A.E., et al. (2017). J Biol Chem, 292(27), 11243-11249.
19. Kim, J., et al. (2019). Infect Immun, 87(1), e00694-18.
20. Yu, Z.T., et al. (2016). J Nutr,146(10),1980-90.
21. Ruiz-Moyano, S., et al. (2013). Appl Environ Microbiol,79(19), 6040-9.
22. Kavanaugh, D.W., et al. (2013), PLoS One, 8(6).
23. Goehring, K.C., et al. (2016). J Nutr,146(12), 2559-66.
24. Newburg, D.S., (2016b). J Thromb Thrombolys, 42(1), 46-55.
25. Allen, J.M., et al. (2019). Front Immunol,10, 1774
26. EFSA 2019a, Panel on Nutrition, Novel Foods and Food Allergens (NDA). (2019). EFSA Journal, 17(6), 5717.
27. EFSA 2019b, Panel on Nutrition, Novel Foods and Food Allergens (NDA). (2019). EFSA Journal,17(12), 5907.
28. EFSA 2020a, Panel on Nutrition, Novel Foods and Food Allergens (NDA) (2020). EFSA Journal,18(5), 6098.
29. EFSA 2020b, Panel on Nutrition, Novel Foods and Food Allergens (NDA). (2020). EFSA Journal, 18(5), 6097.
30. US FDA. GRAS Notice No 815. 2’- fucosyllactose/difucosyllactose.
31. US FDA. GRAS Notice No 833. Lacto-N-tetraose.
32. US FDA. GRAS Notice No 880. 3’-sialyllactose sodium salt.
33. US FDA. GRAS Notice No 881. 6’-sialyllactose sodium salt.
34. Holscher, H. D., et al. (2012). JPEN, 36(1), 106S-117S.
35. Curran, R. (2009). British Society for Immunology. Retrieved from: https://www.immunology.org/public-information/bitesized-immunology/receptors-and-molecules/immunoglobulin-iga#:~:text=Immunoglobulin%20A%20(IgA)%20is%20the,%2C%20both%20extra%2D%20and%20intracellularly.
36. Ziegler, E.E., et al. (2003). Monatsschr Kinderheilk Suppl.1, 151, S65-S71.
37. von Berg, A., et al. (2003). Journal of Allergy And Clinical Immunology, 111(3), 533-540.
38. von Berg, A., et al. (2016). Allergy, 71(2), 210-219.
39. Gappa, M., et al. (2020). Allergy, 00, 1-5.
40. Billeaud, C., et al. (1990). European Journal of Clinical Nutrition, 44, 577-583.
41. Commission Delegated Regulation (EU) 2016/127. (2016). Official Journal of the European Union, L25/1-29.
42. ESFA Panel on Dietetic Products, Nutrition and Allergies (NDA). (2005). EFSA Journal, 280, 1-16.
43. ESFA Panel on Dietetic Products, Nutrition and Allergies (NDA). (2014). EFSA Journal, 12(7), 3760.
44. Szajewska, H., & Horvath, A. (2017). World Allergy Organization Journal, 10(1), 27.
45. Vandenplas, Y., et al. (2019). Nutrition, 57, 268-274.
46. Alexander, D.D., Cabana, M.D. (2010a). JPGN, 50(4),422-30.
47. Sauser, J., et al. (2018). Int Arch Allergy Immunol, 177,123- 134.
48. Hays, T., et al. (2005). Arch Pediatr Adolesc Med,159, 810-816.
49. Baumgartner, M., (1998). Nutr Research, 18, 1425-42.
50. Halken, S., et al. (2000). Pediatric allergy and immunology, 11(3), 149-161.
51. Becker, A., et al. (2004). J Allery Clin Immunol, 113, 650-656.
52. Ngamphaiboon, J., et al. (2009). Asian Biomedicine, 3(3), 245-254.
^ 2‘FL, LNT, 6’SL, 3’SL and DFL (Types of HMO，not sourced from breastmilk) Per 100 mL prepared formula contains 42mg.
#NESTLÉ®NAN®INFINIPRO® contains the same 100% partially hydrolyzed whey protein as BEBA® HA formula in GINI study.
*Complement with balanced diet and regular exercise.
**Compare with control group
***Compare to previous formula
## Compare with the control group, the response of babies after immunization in c-section term infants
△ Contains multivitamins include vitamin A, C&D help support immunity.
* Benefiting from Nestle’s advanced R&D knowledge in children’s metabolic health, immunity and allergy prevention.
■ Protein in NESTLÉ® NAN® INFINIPRO® 4 Children Milk Formula Powder is 100% from whey protein.
▴Babies with high allergy risk
###TUV Austria is a third-party certification body that evaluates and confirms our plant-based plastic packaging according to various international standards and it provides certification related to the bio-based content of our lids and spoons.
We believe that breastfeeding is the ideal nutritional start for babies and we fully support the World Health Organizations recommendation of exclusive breastfeeding for the first six months of life along with the introduction of adequate nutritious complementary foods and continue breastfeeding up to two years of age.
NESTLÉ® NAN® INFINIPRO® 4 milk powder is not a breastmilk substitute. We recommend that you speak to your healthcare professional about how to feed your baby and seek advice on when to introduce this product.